|
Pharmacological Effects of Xanthones as Cardiovascular Protective Agents.
Assess clinically focused product information on Medscape. Medscape Newsletters Key journal articles ranked for newsworthiness and clinical relevance in each specialty, linked to Medline abstracts. Cardiovasc Drug Rev. 2004; 22(2):91-102 (ISSN: 0897-5957) Jiang DJ; Dai Z; Li YJ Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Xiang-Ya Road #90, Changsha 410078, China. Many epidemiological studies indicate that consumption of dietary polyphenolic compounds is beneficial in the prevention of cardiovascular diseases. Xanthones are a class of polyphenolic compounds that commonly occur in plants and have been shown to have extensive biological and pharmacological activities. Recently, the pharmacological properties of xanthones in the cardiovascular system have attracted great interest. Xanthones and xanthone derivatives have been shown to have beneficial effects on some cardiovascular diseases, including ischemic heart disease, atherosclerosis, hypertension and thrombosis. The protective effects of xanthones in the cardiovascular system may be due to their antioxidant, antiinflammatory, platelet aggregation inhibitory, antithrombotic and/or vasorelaxant activities. In particular, the antagonism of endogenous nitric oxide synthase inhibitors by xanthones may represent the basis for improved endothelial function and for reduction of events associated with atherosclerosis. Watch a Video on Mangosteen Fruit Juice |
|